Lembreghts M, Timsit-Berthier M
Laboratoire Universitaire de Psychophysiologie Cognitive Appliquée, Hôpital Le Petit Bourgogne, Liège.
Acta Psychiatr Belg. 1993;93 Spec No:322-42.
According to information processing theory, attention deficits appear to be a nuclear disorder in schizophrenia which the study has been renewed with the development of neurophysiology technique. The originality of our research was to study in a same subject Event-Related-Potentials in three different conditions: passive and active auditory oddball paradigm for Mismatch Negativity (MMN) and P 300, and a simple reaction time task with warming stimulus for the Contingent Negative Variation (CNV). The study was carried out among 20 schizophrenic subjects (paranoid subtype with acute exacerbation, DSM-III-R) and 20 healthy volunteers. Patients differed from controls as the following: a lower amplitude of N1-P2 components of the auditive evoked potentials, a lower amplitude of MMN (absent in 20% of the psychotic subjects), a lower amplitude and a longer latency of P300, and a lower amplitude of CNV. These results suggest a fundamental dysfunction of information processing which involves the early stages of automatic and voluntary attentional cognitive processes in schizophrenia.
根据信息加工理论，注意力缺陷似乎是精神分裂症的核心障碍，随着神经生理学技术的发展，对此的研究得以更新。我们研究的独到之处在于，在同一受试者身上，于三种不同条件下研究事件相关电位：用于失匹配负波（MMN）和P300的被动和主动听觉oddball范式，以及用于关联性负变（CNV）的带有预警刺激的简单反应时任务。该研究在20名精神分裂症患者（偏执型亚型伴急性加重，DSM-III-R）和20名健康志愿者中进行。患者与对照组的差异如下：听觉诱发电位的N1-P2成分波幅较低，MMN波幅较低（20%的精神病受试者中缺失），P300波幅较低且潜伏期较长，以及CNV波幅较低。这些结果表明，信息加工存在根本性障碍，这涉及精神分裂症中自动和自愿注意认知过程的早期阶段。
