Centre for Clinical Research in Neuropsychiatry, Perth 6910, Australia.
Psychiatry Res. 2009 Dec 30;170(2-3):140-9. doi: 10.1016/j.psychres.2008.10.033. Epub 2009 Nov 11.
Few studies have examined electrophysiological functioning in schizophrenia patients with first-rank (passivity) symptoms (FRS). In this study, we conducted a broad assessment of FRS patients' performance using data collected as part of the Western Australia Family Study of Schizophrenia, with a focus on event-related potential (ERP) measures [P50 suppression, mismatch negativity (MMN), the auditory oddball target (P300)], and the antisaccade task. A total of 39 patients (23 patients with, and 16 patients without FRS) and 80 controls were included. The results showed that patients with FRS had significantly reduced amplitude and longer latencies on the P300, as compared to controls. In addition, patients with FRS demonstrated more abnormalities on antisaccade error measures (error rate, self-correction latencies) relative to controls. On these measures, the performance of patients without FRS was not significantly different from controls. P300 and antisaccade error abnormalities in patients with FRS could not be accounted for by clinical variables, medication effects, or cognitive abilities. These results provide support for the proposal that FRS reflect a specific dysfunction in the monitoring and evaluation of sensory information.
很少有研究检查过具有一级（被动性）症状（FRS）的精神分裂症患者的电生理功能。在这项研究中，我们使用作为西澳大利亚州精神分裂症家庭研究的一部分收集的数据，对 FRS 患者的表现进行了广泛评估，重点是事件相关电位（ERP）测量[P50 抑制，失匹配负波（MMN），听觉Oddball 目标（P300）]和反扫视任务。共有 39 名患者（23 名有 FRS，16 名没有 FRS）和 80 名对照者纳入研究。结果表明，与对照组相比，FRS 患者的 P300 的振幅明显降低，潜伏期延长。此外，与对照组相比，FRS 患者在反扫视错误测量（错误率，自我校正潜伏期）上表现出更多的异常。在这些措施中，无 FRS 患者的表现与对照组无显著差异。FRS 患者的 P300 和反扫视错误异常不能用临床变量、药物效应或认知能力来解释。这些结果支持了 FRS 反映了对感觉信息的监测和评估的特定功能障碍的观点。
