Refined localization of the branchiootorenal syndrome gene by linkage and haplotype analysis.
作者信息
Ni L, Wagner M J, Kimberling W J, Pembrey M E, Grundfast K M, Kumar S, Daiger S P, Wells D E, Johnson K, Smith R J
机构信息
Department of Otolaryngology-Head & Neck Surgery, University of Iowa, Iowa City 52242-1078.
出版信息
Am J Med Genet. 1994 Jun 1;51(2):176-84. doi: 10.1002/ajmg.1320510222.
PMID:8092199
Abstract
Branchiootorenal (BOR) syndrome is a common autosomal dominant form of hearing impairment previously mapped to 8q. This report refines the localization of the BOR syndrome gene by haplotype analysis to the interval flanked by markers D8S553 and D8S286. By multipoint linkage analysis, the disease locus most likely is flanked by markers D8S530 and D8S279.
摘要
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