Recker R R
Clin Pharmacol Ther. 1975 Sep;18(3):345-9. doi: 10.1002/cpt1975183345.
The effects of probenecid and hydrochlorothiazide on renal handling of phosphorus during hyperphosphatemia induced by diphosphonate (ethane-1-hydroxy-1, 1-diphosphonate, EHDP) was studied. Measurements of calcium, phosphorus, and creatinine clearance were performed in 2 sessions on each of 3 consecutive days in 10 normal fasting volunteers during the morning hours from 8 A.M. to 12 noon. During 2 to 3 wk thereafter, each subject was treated with EHDP, 30 mg/kg/day. The second group of studies were performed in the same manner as the first except the EHDP administration was continued throughout. EHDP caused elevation of serum phosphorus in all cases. Probenecid did not affect urine phosphorus. Hydrochlorothiazide caused a transient phosphaturia of similar magnitude in the EHDP treated and untreated states. Creatinine clearance was not affected by any of the treatments and urine calcium was decreased by EHDP. It was concluded that hydrochlorothiazide inhibits tubular reabsorption of phosphorus but that it does not affect the mechanism whereby EHDP causes increased tubular reabsorption of phosphorus. Chronic administration of hydrochlorothiazide along with EHDP may inhibit hyperphosphatemia and may change the bone effects of EHDP.
研究了丙磺舒和氢氯噻嗪对二膦酸盐（乙烷-1-羟基-1,1-二膦酸盐，EHDP）诱导的高磷血症期间肾脏对磷处理的影响。在10名正常空腹志愿者中，于上午8点至中午12点的连续3天中的每一天进行2次钙、磷和肌酐清除率的测量。此后2至3周内，每位受试者接受EHDP治疗，剂量为30mg/kg/天。第二组研究以与第一组相同的方式进行，只是全程持续给予EHDP。在所有病例中，EHDP均导致血清磷升高。丙磺舒不影响尿磷。在EHDP治疗和未治疗状态下，氢氯噻嗪均引起类似程度的短暂性磷尿。肌酐清除率不受任何一种治疗的影响，而EHDP使尿钙降低。得出的结论是，氢氯噻嗪抑制肾小管对磷的重吸收，但不影响EHDP导致肾小管对磷重吸收增加的机制。长期联合使用氢氯噻嗪和EHDP可能抑制高磷血症，并可能改变EHDP对骨骼的影响。
