Anthenelli R M, Smith T L, Irwin M R, Schuckit M A
Department of Psychiatry, School of Medicine, University of California, San Diego.
Am J Psychiatry. 1994 Oct;151(10):1468-74. doi: 10.1176/ajp.151.10.1468.
This study compared three methods for identifying type 1 and type 2 alcoholism to determine how well the methods agree. It also evaluated the comparability of each of these schemes to the primary/secondary approach to subgrouping alcoholics.
Fifty male alcoholic inpatients were given diagnoses of primary alcoholism without antisocial personality disorder or primary antisocial personality disorder with secondary alcoholism on the basis of data from structured interviews. Operationalized criteria for type 1 and type 2 alcoholism from three groups of researchers (Gilligan et al., von Knorring et al., and Sullivan et al.) were also used to designate subgroups of the same subjects.
Subgroups of subjects classified as having type 1 or type 2 alcoholism according to the criteria of von Knorring et al. and of Sullivan et al. showed good levels of agreement, but the criteria of Gilligan et al. yielded poor agreement with those of the other two schemes. Subgroups with type 1 or type 2 alcoholism according to the criteria of Sullivan et al. showed significant overlap with subgroups diagnosed according to the primary/secondary alcoholism scheme: there was 73% concordance between the type 1 subgroup and the subgroup with primary alcoholism and 73% concordance between the type 2 subgroup and the subgroup with primary antisocial personality disorder and secondary alcoholism.
There is variability in assigning diagnoses of type 1 and type 2 alcoholism with the use of current methods. Also, type 1/type 2 classifications based primarily on age-at-onset factors significantly overlap with the primary/secondary classifications of alcoholics.
本研究比较了三种用于识别1型和2型酒精中毒的方法,以确定这些方法的一致性程度。同时还评估了每种方案与对酗酒者进行分组的主要/次要方法的可比性。
根据结构化访谈的数据,对50名男性酒精中毒住院患者进行诊断,诊断为无反社会人格障碍的原发性酒精中毒或患有继发性酒精中毒的原发性反社会人格障碍。来自三组研究人员(吉利根等人、冯·诺林等人和沙利文等人)的1型和2型酒精中毒的操作性标准也被用于指定同一组受试者的亚组。
根据冯·诺林等人和沙利文等人的标准分类为患有1型或2型酒精中毒的受试者亚组显示出较好的一致性水平,但吉利根等人的标准与其他两种方案的一致性较差。根据沙利文等人的标准划分的1型或2型酒精中毒亚组与根据原发性/继发性酒精中毒方案诊断的亚组有显著重叠:1型亚组与原发性酒精中毒亚组之间的一致性为73%,2型亚组与患有原发性反社会人格障碍和继发性酒精中毒的亚组之间的一致性为73%。
使用当前方法对1型和2型酒精中毒进行诊断存在差异。此外,主要基于发病年龄因素的1型/2型分类与酗酒者的原发性/继发性分类有显著重叠。