人体中苯佐卡因相关性高铁血红蛋白血症的前瞻性评估。

A prospective evaluation of benzocaine-associated methemoglobinemia in human beings.

作者信息

Guertler A T, Pearce W A

机构信息

Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, Washington.

出版信息

Ann Emerg Med. 1994 Oct;24(4):626-30. doi: 10.1016/s0196-0644(94)70272-1.

DOI:10.1016/s0196-0644(94)70272-1

PMID:8092589

Abstract

STUDY OBJECTIVE

This study determined the frequency and severity of benzocaine-associated methemoglobinemia in routine clinical use.

DESIGN

Prospective, crossover, convenience study.

SETTING

Gastroenterology clinic at a US Army medical center functioning as a community hospital and tertiary referral center.

PARTICIPANTS

Healthy adult volunteers and patient volunteers undergoing an upper gastrointestinal endoscopic procedure.

INTERVENTIONS

Baseline methemoglobin levels were measured. Subjects then received a 2-second spray of benzocaine to the oropharynx. Venous blood for methemoglobin analysis was collected 20, 40, and 60 minutes after benzocaine dosing and analyzed using a co-oximeter.

RESULTS

A statistically significant (P < .05) increase in methemoglobin level between baseline (0.8 +/- 0.2%) and 20-, 40-, and 60-minute measurements (0.9 +/- 0.2%) was identified using one-way analysis of variance followed by Fisher's protected least-squares difference.

CONCLUSION

A 2-second spray of 20% benzocaine applied to the oropharynx of human beings induces a statistically significant, but clinically insignificant, increase in methemoglobin levels.

摘要