Hanlon D P, Shuman S
Experientia. 1975 Sep 15;31(9):1005-6. doi: 10.1007/BF02326924.
The antithyroid drug, methimazole (1-methyl-2-thiolimidazole), is a powerful chelator of cupric ion. This is reflected in its ability to selectively inhibit certain copper oxidases. Uricase, ascorbic oxidase and monoamine oxidase are not affected. Ceruloplasmin oxidase is slightly inhibited and tyrosinase is markedly inhibited by methimazole.
抗甲状腺药物甲巯咪唑（1-甲基-2-硫代咪唑）是一种强大的铜离子螯合剂。这体现在它能够选择性抑制某些铜氧化酶。尿酸酶、抗坏血酸氧化酶和单胺氧化酶不受影响。甲巯咪唑对铜蓝蛋白氧化酶有轻微抑制作用，对酪氨酸酶有显著抑制作用。
