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3-氨基-L-酪氨酸对蘑菇酪氨酸酶的抑制作用：该酶活性位点的分子探测

Inhibition of mushroom tyrosinase by 3-amino-L-tyrosine: molecular probing of the active site of the enzyme.

作者信息

Maddaluno J F, Faull K F

机构信息

Nancy Pritzker Laboratory of Behavioral Neurochemistry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305.

出版信息

Experientia. 1988 Oct 15;44(10):885-7. doi: 10.1007/BF01941189.

DOI:10.1007/BF01941189
PMID:3141207
Abstract

We report the ability of 3-amino-L-tyrosine to act as a fully reversible competitive inhibitor of mushroom tyrosinase. The inhibition is linked to the ortho-aminophenol structure, and a copper bridging mechanism in the active site is proposed.

摘要

我们报道了3-氨基-L-酪氨酸作为蘑菇酪氨酸酶的一种完全可逆竞争性抑制剂的能力。这种抑制作用与邻氨基苯酚结构有关，并提出了活性位点中的铜桥接机制。

相似文献

1
Inhibition of mushroom tyrosinase by 3-amino-L-tyrosine: molecular probing of the active site of the enzyme.3-氨基-L-酪氨酸对蘑菇酪氨酸酶的抑制作用：该酶活性位点的分子探测
Experientia. 1988 Oct 15;44(10):885-7. doi: 10.1007/BF01941189.
2
Phosphonic analogues of tyrosine and 3,4-dihydroxyphenylalanine (dopa) influence mushroom tyrosinase activity.酪氨酸和3,4-二羟基苯丙氨酸（多巴）的膦酸类似物会影响蘑菇酪氨酸酶的活性。
Biochem J. 1987 Feb 15;242(1):81-8. doi: 10.1042/bj2420081.
3
Effect of methimazole on the activity of mushroom tyrosinase.甲巯咪唑对蘑菇酪氨酸酶活性的影响。
Biochem J. 1986 Apr 1;235(1):91-6. doi: 10.1042/bj2350091.
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pH-dependent interconvertible forms of mushroom tyrosinase with different kinetic properties.具有不同动力学性质的蘑菇酪氨酸酶的pH依赖性可相互转换形式。
Pigment Cell Res. 1989 Jan-Feb;2(1):8-13. doi: 10.1111/j.1600-0749.1989.tb00151.x.
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Oxygenation of fluorinated tyrosines by mushroom tyrosinase releases fluoride ion.
Arch Biochem Biophys. 1990 Jan;276(1):65-9. doi: 10.1016/0003-9861(90)90010-v.
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[Alpha-hydrazinophloretic acid, competitive inhibitor of fungal tyrosinase].
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Multifunctional Tyrosinase Inhibitor Peptides with Copper Chelating, UV-Absorption and Antioxidant Activities: Kinetic and Docking Studies.具有铜螯合、紫外线吸收和抗氧化活性的多功能酪氨酸酶抑制剂肽：动力学和对接研究
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本文引用的文献

1
Structures and functions of the phenolase complex.酚酶复合体的结构与功能。
Nature. 1956 Jan 14;177(4498):79-81. doi: 10.1038/177079a0.
2
Molecular basis of substrate and inhibitory specificity of tyrosinase: phenolic compounds.酪氨酸酶的底物和抑制特异性的分子基础：酚类化合物
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Extended X-ray absorption fine structure study of the coupled binuclear copper active site of tyrosinase from Neurospora crassa.
酪氨酸酶活性位点模型上竞争性抑制剂对接的研究：联合broken-symmetry/Spin-Flip DFT 计算和 ELF 拓扑分析的见解。
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Inhibition of melanoma tyrosinase by fusaric acid.
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Chorismate mutase-prephenate dehydrogenase from Escherichia coli: cooperative effects and inhibition by L-tyrosine.来自大肠杆菌的分支酸变位酶-预苯酸脱氢酶：协同效应及L-酪氨酸的抑制作用
Arch Biochem Biophys. 1985 Aug 1;240(2):646-54. doi: 10.1016/0003-9861(85)90072-4.
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Optimization of hydroxylation of tyrosine and tyrosine-containing peptides by mushroom tyrosinase.蘑菇酪氨酸酶对酪氨酸及含酪氨酸肽的羟基化反应的优化
Biochim Biophys Acta. 1986 Jul 25;872(1-2):98-103. doi: 10.1016/0167-4838(86)90152-4.
7
Copper ion binding and enzyme inhibitory properties of the antithyroid drug methimazole.抗甲状腺药物甲巯咪唑的铜离子结合及酶抑制特性
Experientia. 1975 Sep 15;31(9):1005-6. doi: 10.1007/BF02326924.