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重组人生长激素治疗期间出现症状性非胰岛素依赖型糖尿病

Symptomatic non-insulin-dependent diabetes mellitus during therapy with recombinant human growth hormone.

作者信息

Botero D, Danon M, Brown R S

机构信息

Department of Pediatrics, University of Massachusetts Medical School, Worcester 01655.

出版信息

J Pediatr. 1993 Oct;123(4):590-2. doi: 10.1016/s0022-3476(05)80959-x.

DOI:10.1016/s0022-3476(05)80959-x
PMID:8093122
Abstract

In a 12-year-old girl, hyperglycemia and an elevated glycohemoglobin concentration developed after therapy with growth hormone for familial short stature. Both clinical and biochemical abnormalities disappeared after therapy was discontinued. The insulin response to an oral glucose tolerance test was abnormal 3 months after discontinuation of growth hormone; 18 months later, it remained delayed but was normal quantitatively.

摘要

一名12岁女孩因家族性身材矮小接受生长激素治疗后出现高血糖和糖化血红蛋白浓度升高。停止治疗后,临床和生化异常均消失。停止生长激素治疗3个月后,口服葡萄糖耐量试验的胰岛素反应异常;18个月后,反应仍延迟,但数量上正常。

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引用本文的文献

1
Growth hormone treatment in children: review of safety and efficacy.儿童生长激素治疗:安全性与疗效综述
Paediatr Drugs. 2004;6(2):93-106. doi: 10.2165/00148581-200406020-00003.