Gulley L R, Nemeroff C B
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Ga. 30322.
J Clin Psychiatry. 1993 Jan;54 Suppl:16-9.
A recognition of the clinical overlap of symptoms of anxiety disorders and those of affective disorders has brought with it a need to move beyond descriptive definitions of the syndromes to an etiologic and neurobiological understanding of their psychopathology. The authors discuss the neurobiological basis of mixed depression-anxiety states with special attention to the literature on pharmacologic treatment outcome studies, neurotransmitters in anxiety and depression, and the hypothalamic-pituitary-adrenal axis.
认识到焦虑症和情感障碍症状在临床上的重叠，使得有必要超越对这些综合征的描述性定义，转而从病因学和神经生物学角度理解其精神病理学。作者们讨论了混合性抑郁焦虑状态的神经生物学基础，特别关注药物治疗结果研究、焦虑和抑郁中的神经递质以及下丘脑 - 垂体 - 肾上腺轴方面的文献。
