Stahl S M
Clinical Neuroscience Research Center, University of California, San Diego 92122, USA.
J Clin Psychiatry. 1997;58 Suppl 8:20-6.
Although depressive and anxious symptoms frequently coexist, most studies tend to dichotomize anxiety disorders from depression. Consequently, pharmacologic agents are designated as antidepressants or anxiolytics. A number of developments are reversing this trend. One is changes in conceptualization of generalized anxiety disorder (GAD) and major depressive disorder to recognize the frequent existence of simultaneous symptoms of anxiety and depression in patients with related affective and anxiety disorders. A second is the increasing recognition that subsyndromal symptoms of anxiety and depression frequently exist that do not reach thresholds for GAD or depression but that may decompensate to overt anxiety disorder or depression. A third is the discovery of partial agonists for serotonin1A receptor subtypes that have promising efficacy in mixed depression and anxiety.
尽管抑郁症状和焦虑症状常常同时存在，但大多数研究倾向于将焦虑症与抑郁症区分开来。因此，药物被分为抗抑郁药或抗焦虑药。一些新进展正在扭转这一趋势。一是广泛性焦虑障碍（GAD）和重度抑郁症概念化的变化，以认识到相关情感和焦虑障碍患者中焦虑和抑郁症状经常同时存在。二是越来越认识到焦虑和抑郁的亚综合征症状经常存在，这些症状未达到GAD或抑郁症的阈值，但可能会恶化为明显的焦虑症或抑郁症。三是发现了5-羟色胺1A受体亚型的部分激动剂，它们在混合性抑郁和焦虑中具有有前景的疗效。
