van Neer F, Zemelman V, Cerio R, Langtry J, Staughton R C
Skin and Therapeutics Research Laboratory, Westminster Hospital, London, U.K.
Br J Dermatol. 1993 Jan;128(1):29-33. doi: 10.1111/j.1365-2133.1993.tb00142.x.
Factor XIIIa-positive dermal dendrocytes (FXIIIa+ dd) may have an important role in the pathogenesis of psoriasis, in that their numbers are increased in lesional skin compared with non-lesional skin. Moreover, in AIDS-associated Kaposi's sarcoma the number of these cells is also increased, in comparison with the classical type of Kaposi's sarcoma. In addition, patients suffering from HIV-1 infection may develop severe psoriasis. The aim of this study was to examine the distribution of FXIIIa+ dd in lesional and non-lesional skin from seven psoriatic patients with positive HIV-1 serology, and compare the results with age-, sex-, and site-matched HIV-1-negative psoriatic patients. In both patient groups there was an increase of FXIIIa+ dd in the papillary dermis in lesional skin, compared with non-lesional skin (HIV+ [P = 0.007]; HIV- [P = 0.0006]). Positive cells were also observed within the epidermis in lesional skin in both groups. However, there was no significant difference between HIV-1+ and HIV-1- groups in the number of FXIIIa+ dd in the epidermis and dermis (P > 0.05). These findings suggest that, if FXIIIa+ dd do have a role in psoriasis, deterioration of this condition in HIV-1+ patients is not due to proliferation of dermal dendrocytes.
因子 XIIIa 阳性真皮树突状细胞（FXIIIa+ dd）可能在银屑病的发病机制中起重要作用，因为与非皮损皮肤相比，其在皮损皮肤中的数量增加。此外，与经典型卡波西肉瘤相比，在艾滋病相关卡波西肉瘤中这些细胞的数量也增加。另外，感染 HIV-1 的患者可能会发展为严重的银屑病。本研究的目的是检查 7 例 HIV-1 血清学阳性的银屑病患者皮损和非皮损皮肤中 FXIIIa+ dd 的分布情况，并将结果与年龄、性别和部位匹配的 HIV-1 阴性银屑病患者进行比较。在两个患者组中，与非皮损皮肤相比，皮损皮肤乳头层真皮中的 FXIIIa+ dd 均增加（HIV+组[P = 0.007]；HIV-组[P = 0.0006]）。两组皮损皮肤的表皮内也观察到阳性细胞。然而，HIV-1+组和 HIV-1-组在表皮和真皮中 FXIIIa+ dd 的数量上没有显著差异（P > 0.05）。这些发现表明，如果 FXIIIa+ dd 在银屑病中确实起作用，那么 HIV-1+患者病情的恶化并非由于真皮树突状细胞的增殖。
