Nickoloff B J, Griffiths C E
Department of Pathology, University of Michigan Medical Center, Ann Arbor 48109-0602.
Am J Pathol. 1989 Nov;135(5):793-800.
Kaposi's sarcoma is a neoplasm that develops as multifocal lesions, often involving the skin, characterized by a complex histologic picture including numerous vascular spaces, perivascular and interstitial spindle-shaped cells, and extravasated erythrocytes, lymphocytes, and plasma cells. Using an antibody against factor XIIIa, which identifies dermal dendrocytes, numerous factor XIIIa-positive dermal dendrocytes were detected among the spindle-shaped cells in 12 acquired immune deficiency syndrome (AIDS)-associated, and five non-AIDS-associated Kaposi's sarcoma lesions. The factor XIIIa-positive dermal dendrocytes were also increased in histologic simulators of Kaposi's sarcoma such as dermatofibroma, angiomatoid malignant fibrous histiocytoma, granuloma annulare, and early wound healing, but were absent in keloids. The increased number of dermal dendrocytes, which are often in an angiocentric configuration and which also express CD4, lymphocyte function associated antigen-1 (LFA-1), and Leu M3 in Kaposi's sarcoma, may be important to the angioproliferative response. The results suggested that the spindle-shaped cells that are present in a variety of cutaneous lesions are dermal dendrocytes and belong to the reticuloendothelial system, unlike other mesenchymal cell types such as the endothelial cell. Apparently a diverse array of stimuli, including human immunodeficiency virus type-1 (HIV-1) infection and trauma, can stimulate the accumulation of factor XIIIa expressing dermal dendrocytes in the skin. These cells can then participate in different stages of a variety of cutaneous alterations including Kaposi's sarcoma, dermatofibroma, granuloma annulare, and early wound healing. Thus, the factor XIIIa-positive dermal dendrocyte is a common cellular denominator among diverse clinical entities that share some histologic features.
卡波西肉瘤是一种以多灶性病变形式发展的肿瘤，常累及皮肤，其组织学表现复杂，包括众多血管腔隙、血管周围和间质梭形细胞，以及外渗的红细胞、淋巴细胞和浆细胞。使用针对ⅩⅢa因子的抗体（该抗体可识别真皮树突状细胞），在12例获得性免疫缺陷综合征（AIDS）相关的和5例非AIDS相关的卡波西肉瘤病变的梭形细胞中检测到大量ⅩⅢa因子阳性的真皮树突状细胞。在卡波西肉瘤的组织学模拟病变如皮肤纤维瘤、血管瘤样恶性纤维组织细胞瘤、环状肉芽肿和早期伤口愈合中，ⅩⅢa因子阳性的真皮树突状细胞也增多，但在瘢痕疙瘩中不存在。在卡波西肉瘤中，数量增多的真皮树突状细胞常呈血管中心性分布，且还表达CD4、淋巴细胞功能相关抗原-1（LFA-1）和Leu M3，这可能对血管增殖反应很重要。结果表明，存在于多种皮肤病变中的梭形细胞是真皮树突状细胞，属于网状内皮系统，这与其他间充质细胞类型如内皮细胞不同。显然，包括1型人类免疫缺陷病毒（HIV-1）感染和创伤在内的多种刺激，可刺激皮肤中表达ⅩⅢa因子的真皮树突状细胞聚集。这些细胞随后可参与包括卡波西肉瘤、皮肤纤维瘤、环状肉芽肿和早期伤口愈合在内的多种皮肤改变的不同阶段。因此，ⅩⅢa因子阳性的真皮树突状细胞是具有一些组织学特征的不同临床实体中的常见细胞成分。
