在芽孢萌发过程中核糖核酸合成存在温度敏感损伤的枯草芽孢杆菌突变体。
Mutant of Bacillus subtilis with a temperature-sensitive lesion in ribonucleic acid synthesis during germination.
作者信息
Albertini A M, Galizzi A
出版信息
J Bacteriol. 1975 Oct;124(1):14-25. doi: 10.1128/jb.124.1.14-25.1975.
Abstract
We have isolated a mutant of Baccillus subtilis with a temperature-sensitive lesion in the process of spore germination. The temperature-sensitive mutation affects only germination and outgrowth, and the earliest defect observed is an early block of ribonucleic acid synthesis during germination at 46 C. Upon return to 35 C there is a complete repair of the impaired function, even in the absence of protein synthesis. Protein synthesis inhibition during germination of the mutant spores at 46 C has the effect of increasing the amount of ribonucleic acid made. The temperature-sensitive mutation is located near aroI.
摘要
我们已经分离出一株枯草芽孢杆菌突变体，其在孢子萌发过程中存在温度敏感损伤。该温度敏感突变仅影响萌发和生长，观察到的最早缺陷是在46℃萌发期间核糖核酸合成的早期阻断。回到35℃后，即使在没有蛋白质合成的情况下，受损功能也能完全修复。在46℃下突变体孢子萌发期间抑制蛋白质合成具有增加核糖核酸合成量的作用。该温度敏感突变位于aroI附近。
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