Dahlitz M, Parkes J D
University Department of Neurology, Institute of Psychiatry, London, UK.
Lancet. 1993 Feb 13;341(8842):406-7. doi: 10.1016/0140-6736(93)92992-3.
Sleep paralysis is a common condition with a prevalence of 5-62%. Although most affected people have single or infrequent episodes, sleep paralysis may be recurrent, or occur in association with the narcoleptic syndrome. In a study of 22 subjects with frequent sleep paralysis and also excessive daytime sleepiness, episodes continued for between 5 and 35 years. In contrast to subjects with the narcoleptic syndrome, these patients did not have cataplexy, daytime sleepiness and insomnia were less severe, and there was no HLA DR2(15) or DQ1(6) association. Sleep paralysis was familial in 19 of these subjects. A non-HLA linked genetic factor, in addition to environmental factors, may thus predispose to sleep paralysis.
睡眠瘫痪症是一种常见病症，患病率为5%至62%。尽管大多数患者仅有单次发作或发作不频繁，但睡眠瘫痪症可能会反复发作，或与发作性睡病综合征相关联。在一项针对22名频繁出现睡眠瘫痪症且伴有过度日间嗜睡症状的受试者的研究中，发作持续了5至35年。与发作性睡病综合征患者不同，这些患者没有猝倒症状，日间嗜睡和失眠症状较轻，且不存在HLA DR2(15)或DQ1(6)关联。在这些受试者中，有19人存在家族性睡眠瘫痪症。因此，除环境因素外，一种与HLA不相关的遗传因素可能易引发睡眠瘫痪症。
