选择性多巴胺D-1受体激动剂SK&F 38393和CY 208-243可减少大鼠的蔗糖假饲。

Selective dopamine D-1 receptor agonists, SK&F 38393 and CY 208-243 reduce sucrose sham-feeding in the rat.

作者信息

Cooper S J, Francis J, Barber D J

机构信息

Laboratory of Psychopharmacology, School of Psychology, University of Birmingham, U.K.

出版信息

Neuropharmacology. 1993 Jan;32(1):101-2. doi: 10.1016/0028-3908(93)90135-p.

DOI:10.1016/0028-3908(93)90135-p

PMID:8094232

Abstract

Gastric-fistulated rats were trained to sham-feed a 10% sucrose solution in a 60 min test. The selective dopamine D-1 receptor agonists, SK&F 38393 (3 and 10 mg/kg, s.c.) and CY 208-243 (1 and 3 mg/kg, s.c.) both produced dose-related reductions in sham-feeding. These effects were present in the first 5 min of the test period, and persisted throughout the remainder of the test. The data confirm and extend results for an anorectic effect of SK&F 38393 and demonstrate, for the first time, a similar anorectic effect of CY 208-243.

摘要

对具有胃瘘的大鼠进行训练，使其在60分钟的测试中假饲10%的蔗糖溶液。选择性多巴胺D-1受体激动剂SK&F 38393（3毫克/千克和10毫克/千克，皮下注射）和CY 208-243（1毫克/千克和3毫克/千克，皮下注射）均产生了与剂量相关的假饲减少。这些效应在测试期的前5分钟出现，并在测试的其余时间持续存在。这些数据证实并扩展了SK&F 38393的厌食作用的结果，并且首次证明了CY 208-243具有类似的厌食作用。