Noguchi M, Koyasaki N, Ohta N, Kitagawa H, Earashi M, Thomas M, Miyazaki I, Mizukami Y
Department of Surgery (II), Kanazawa University Hospital, School of Medicine, Kanazawa University, Japan.
Arch Surg. 1993 Feb;128(2):242-6. doi: 10.1001/archsurg.1993.01420140119020.
We evaluated the relationship among DNA ploidy, c-erb B-2 oncoprotein expression, and clinicopathologic prognostic factors, especially axillary and internal mammary node metastases, and their value in estimating the prognosis in 128 patients with operable breast cancer. There were significant correlations between DNA ploidy and clinical stage, tumor size, or axillary or internal mammary lymph node metastases, and between c-erb B-2 expression and clinical stage or axillary lymph node metastases. In a univariate study, overall or disease-free survival was significantly correlated to clinical stage, tumor size, DNA ploidy, c-erb B-2 expression, and axillary and internal mammary node metastases. In a multivariate study, however, only axillary and internal mammary node metastases were recognized as independent factors on overall survival, whereas on disease-free survival, only axillary lymph node metastases were identified as an independent indicator. Since the DNA ploidy status and c-erb B-2 expression were closely correlated with the axillary and/or internal mammary lymph node metastases, they did not appear as independent prognostic factors in this small series.
我们评估了128例可手术乳腺癌患者的DNA倍体、c-erb B-2癌蛋白表达与临床病理预后因素之间的关系，尤其是腋窝和内乳淋巴结转移情况，以及它们在评估预后方面的价值。DNA倍体与临床分期、肿瘤大小、腋窝或内乳淋巴结转移之间存在显著相关性，c-erb B-2表达与临床分期或腋窝淋巴结转移之间也存在显著相关性。在单因素研究中，总生存期或无病生存期与临床分期、肿瘤大小、DNA倍体、c-erb B-2表达以及腋窝和内乳淋巴结转移显著相关。然而，在多因素研究中，只有腋窝和内乳淋巴结转移被认为是总生存期的独立因素，而在无病生存期方面，只有腋窝淋巴结转移被确定为独立指标。由于DNA倍体状态和c-erb B-2表达与腋窝和/或内乳淋巴结转移密切相关，在这个小样本系列中它们未表现为独立的预后因素。
