Noguchi M, Taniya T, Ohta N, Koyasaki N, Miyazaki I, Mizukami Y
Operation Center, Kanazawa University Hospital, School of Medicine, Japan.
Breast Cancer Res Treat. 1991 Sep;19(1):23-31. doi: 10.1007/BF01975201.
We evaluated the relationship between the DNA ploidy status and other variable prognostic factors, especially regional lymph node metastases, in 121 patients with invasive ductal carcinoma of breast, together with the value of these factors in estimating the prognostic of breast cancer. The ploidy status was diploid in 40% of the patients, and aneuploid in 60%. A significantly higher incidence of aneuploidy was found in patients with more than 4 positive axillary lymph nodes, positive internal mammary lymph nodes, or clinical stage 3 of malignancy. In a univariate study, overall survival and disease-free survival were significantly correlated with axillary and internal mammary lymph node metastases, tumor size, and clinical stage of malignancy. The disease-free survival rates for the diploid group tended to be somewhat higher than those for the aneuploid group of patients without axillary lymph node metastases. In the multivariate analysis, however, only axillary lymph node metastasis was significantly correlated with overall survival and disease-free survival. There was also a trend for the internal mammary lymph node metastases to be correlated with survival. As the DNA ploidy status was closely correlated with the axillary and internal mammary lymph node metastases, it did not appear to be an independent prognostic factor in this small series.
我们评估了121例乳腺浸润性导管癌患者的DNA倍体状态与其他可变预后因素之间的关系，尤其是区域淋巴结转移情况，以及这些因素在评估乳腺癌预后方面的价值。40%的患者倍体状态为二倍体，60%为非整倍体。在腋窝淋巴结阳性超过4个、胸骨旁淋巴结阳性或临床恶性分期为3期的患者中，非整倍体的发生率显著更高。在单因素研究中，总生存期和无病生存期与腋窝和胸骨旁淋巴结转移、肿瘤大小以及临床恶性分期显著相关。在无腋窝淋巴结转移的患者中，二倍体组的无病生存率往往略高于非整倍体组。然而，在多因素分析中，只有腋窝淋巴结转移与总生存期和无病生存期显著相关。胸骨旁淋巴结转移与生存率也存在一定的相关性趋势。由于DNA倍体状态与腋窝和胸骨旁淋巴结转移密切相关，在这个小样本系列中，它似乎不是一个独立的预后因素。
