Thanoo B C, Sunny M C, Jayakrishnan A
Polymer Chemistry Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
J Pharm Pharmacol. 1993 Jan;45(1):21-4. doi: 10.1111/j.2042-7158.1993.tb03672.x.
Polycarbonate microspheres loaded with aspirin, griseofulvin and p-nitroaniline were prepared by a solvent evaporation technique. High drug loading (> 50%) was achieved by this process. Drug-loaded microspheres were found to float on simulated gastric fluid and intestinal fluid. Drug-release studies were carried out in these fluids at 37 degrees C. Increasing the drug to polymer ratio in the microspheres increased both their mean particle size and the release rate of the drugs. It was concluded that sustained delivery of drugs could be effected using this matrix.
采用溶剂蒸发技术制备了负载阿司匹林、灰黄霉素和对硝基苯胺的聚碳酸酯微球。通过该工艺实现了高载药量（>50%）。发现载药微球漂浮在模拟胃液和肠液上。在37℃下于这些液体中进行了药物释放研究。增加微球中药物与聚合物的比例会增加其平均粒径和药物释放速率。得出的结论是，使用这种基质可以实现药物的持续递送。
