Graves G A, Noyes F R, Villanueva A R
J Biomed Mater Res. 1975 Jul;9(4):17-22. doi: 10.1002/jbm.820090405.
Sixteen ceramic specimens were implanted in the femur of mature rhesus monkeys. The specimens consisted of four groups of a basic calcium aluminate composition with additions of 5, 10, 15 and 20 wt% phosphorous pentoxide (P2O5). The increasing amounts of P2O5 caused variations in the resorption rate, microstructure and surface characteristics of the implant. The influence of these variables on bone and tissue growth within and about the implant was investigated. After sacrifice the ceramic-bone specimens were studied by a tetracycline-based histological analysis, scanning electron microscopy and energy dispersive analysis. The results indicate an increase in mesenchymal cell proliferation, fibrous and bone tissue formation at the ceramic tissue interface and within the implant with increasing concentrations of P2O5. The results obtained from the study did not furnish sufficient evidence to differentiate between the direct chemical influence the increasing P2O5 had on osseous tissue formation or the indirect influence that may have resulted from its effect on the ceramic microstructure and morphology.
将16个陶瓷样本植入成年恒河猴的股骨中。样本由四组基本的铝酸钙成分组成，分别添加了5%、10%、15%和20%（重量）的五氧化二磷（P2O5）。P2O5含量的增加导致植入物的吸收速率、微观结构和表面特性发生变化。研究了这些变量对植入物内部和周围骨组织及组织生长的影响。处死后，通过基于四环素的组织学分析、扫描电子显微镜和能量色散分析对陶瓷-骨样本进行研究。结果表明，随着P2O5浓度的增加，间充质细胞增殖、纤维和骨组织在陶瓷-组织界面及植入物内部形成增加。该研究获得的结果没有提供足够的证据来区分P2O5增加对骨组织形成的直接化学影响或其对陶瓷微观结构和形态的影响可能产生的间接影响。
