Tomita Y, Kimura M, Tanikawa T, Nishiyama T, Morishita H, Takeda M, Fujiwara M, Sato S
Department of Urology, Niigata University School of Medicine, Japan.
J Urol. 1993 Mar;149(3):659-63. doi: 10.1016/s0022-5347(17)36174-8.
Expression of intercellular adhesion molecule-1 (ICAM-1) and major histocompatibility complex (MHC) antigens, and characterization of tumor-infiltrating mononuclear cells (TIM) were examined immunohistologically in 10 specimens of seminoma. ICAM-1 and MHC antigens were not detected on normal spermatogenic cells. ICAM-1 and MHC class I antigens were variably expressed in 7 and 9 seminomas, respectively, whereas class II antigens were not detected. Although the degree of expression of ICAM-1 and MHC antigens was not correlated with any clinical or histopathological factors, neither of the antigens was detected on an anaplastic seminoma. Various numbers of TIM were detected in all of the seminoma, and comprised mainly T cells bearing the lymphocyte function-associated antigen (LFA)-1. No significant correlation was noticed between the degree of lymphocyte infiltration and ICAM-1 or MHC antigen expression. Although ICAM-1 and MHC class I antigens were expressed in seminoma, possibly facilitating an anti-tumor reaction of host, their expression remained low in several cases, despite marked lymphocyte infiltration within the tumor.
对10例精原细胞瘤标本进行免疫组织学检查，检测细胞间黏附分子-1（ICAM-1）和主要组织相容性复合体（MHC）抗原的表达，并对肿瘤浸润单核细胞（TIM）进行特征分析。在正常生精细胞上未检测到ICAM-1和MHC抗原。在7例和9例精原细胞瘤中分别检测到ICAM-1和MHC I类抗原的不同程度表达，而未检测到II类抗原。虽然ICAM-1和MHC抗原的表达程度与任何临床或组织病理学因素均无相关性，但在间变性精原细胞瘤上均未检测到这两种抗原。在所有精原细胞瘤中均检测到数量不等的TIM，主要由携带淋巴细胞功能相关抗原（LFA）-1的T细胞组成。淋巴细胞浸润程度与ICAM-1或MHC抗原表达之间未发现显著相关性。虽然ICAM-1和MHC I类抗原在精原细胞瘤中表达，可能有助于宿主的抗肿瘤反应，但在一些病例中，尽管肿瘤内淋巴细胞浸润明显，其表达水平仍然较低。
