Thompson D F, Carter J R
Department of Pharmacy Practice, Southwestern Oklahoma State University, Weatherford.
Pharmacotherapy. 1993 Jan-Feb;13(1):37-45.
Gynecomastia is a relatively common physical finding in men. A wide variety of drugs have been implicated in its cause. Sufficient evidence in the literature suggests that calcium-channel blockers, cancer chemotherapeutic agents, and histamine2-receptor blockers may play a role in the disorder. Evidence for digitalis glycosides and neuroleptic agents is insufficient. Ketoconazole and spironolactone can also produce gynecomastia, and data for marijuana are contradictory. Large numbers of drugs have only case reports of temporal association with the disorder.
男性乳房肥大是男性中相对常见的体征。多种药物被认为与该病的病因有关。文献中的充分证据表明，钙通道阻滞剂、癌症化疗药物和组胺2受体阻滞剂可能在该病症中起作用。洋地黄苷和抗精神病药物的证据不足。酮康唑和螺内酯也可导致男性乳房肥大，而关于大麻的数据相互矛盾。大量药物仅有与该病症存在时间关联的病例报告。
