Peters K M, Klosterhalfen B, Zwadlo-Klarwasser G, Koberg K, Rosendahl T, Zilkens K W
Orthopädische Klinik, RWTH, Aachen.
Unfallchirurg. 1993 Jan;96(1):29-33.
In patients with chronic post-traumatic osteomyelitis, several deficits in immunological response were demonstrated. In a prospective trial of 20 patients with proven osteomyelitis, histological analysis of lymphocyte subsets in peripheral blood and in the infected bone tissue was performed. The effects of chronic osteomyelitis on lymphocyte subsets in the peripheral blood and in inflamed tissue were only slight. The T4/T8 ratio was diminished in only two patients and had no relationship to the clinical course. Interleukin 2 receptor determination was negative in 83% of biopsies of infected tissue. Osteomyelitis may possibly cause a defect in lymphocyte/macrophage cooperation.
在慢性创伤后骨髓炎患者中，已证实存在多种免疫反应缺陷。在一项针对20例已确诊骨髓炎患者的前瞻性试验中，对外周血和感染骨组织中的淋巴细胞亚群进行了组织学分析。慢性骨髓炎对外周血和炎症组织中淋巴细胞亚群的影响很小。仅2例患者的T4/T8比值降低，且与临床病程无关。83%的感染组织活检中白细胞介素2受体测定为阴性。骨髓炎可能会导致淋巴细胞/巨噬细胞协作缺陷。
