al Badri A M, Foulis A K, Todd P M, Gariouch J J, Gudgeon J E, Stewart D G, Gracie J A, Goudie R B
Department of Pathology, Royal Infirmary, Glasgow, UK.
J Pathol. 1993 Feb;169(2):203-6. doi: 10.1002/path.1711690205.
The relationship between damage to cutaneous melanocytes and antimelanocyte autoimmunity in vitiligo is unclear. We have demonstrated abnormal expression of MHC class II molecules by perilesional melanocytes in 13/21 patients with vitiligo and a six-fold increase in the number expressing the intercellular adhesion molecule ICAM-1. These molecules have important roles in normal antigen presentation and activation of helper T lymphocytes, and their expression by melanocytes may contribute to the abnormal immune response in vitiligo. MHC class II is not expressed by melanocytes in psoriasis and is unlikely to be induced in vitiligo by cytokines released from activated non-melanocyte-specific T lymphocytes.
白癜风中皮肤黑素细胞损伤与抗黑素细胞自身免疫之间的关系尚不清楚。我们已经证实在21例白癜风患者中有13例其皮损周围的黑素细胞存在MHC II类分子异常表达，且表达细胞间黏附分子ICAM-1的数量增加了6倍。这些分子在正常抗原呈递及辅助性T淋巴细胞激活过程中起重要作用，黑素细胞对它们的表达可能促使白癜风中出现异常免疫反应。银屑病中的黑素细胞不表达MHC II类分子，白癜风中其也不太可能由活化的非黑素细胞特异性T淋巴细胞释放的细胞因子所诱导。
