转移性乳腺癌患者接受紫杉醇和阿霉素治疗后引发的盲肠炎。
Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer.
作者信息
Pestalozzi B C, Sotos G A, Choyke P L, Fisherman J S, Cowan K H, O'Shaughnessy J A
机构信息
Medicine Branch, National Cancer Institute, Bethesda, MD 20892.
出版信息
Cancer. 1993 Mar 1;71(5):1797-800. doi: 10.1002/1097-0142(19930301)71:5<1797::aid-cncr2820710514>3.0.co;2-b.
BACKGROUND
Typhlitis is being recognized with increasing frequency as a serious complication of aggressive chemotherapy for hematologic and solid malignancies.
METHODS
In this report the authors describe two cases of typhlitis in patients with metastatic breast cancer treated with taxol and doxorubicin.
RESULTS
Both cases occurred during the first cycle of treatment with taxol (180 mg/m2) and doxorubicin (75 mg/m2), being given simultaneously as 72-hour continuous intravenous infusions.
CONCLUSION
Two cases of typhlitis have occurred after combined treatment with taxol and doxorubicin, while typhlitis has not been described after treatment with either drug alone.
背景
盲肠炎作为血液系统和实体恶性肿瘤强化化疗的一种严重并发症，其被认识的频率日益增加。
方法
在本报告中，作者描述了两例接受紫杉醇和阿霉素治疗的转移性乳腺癌患者发生盲肠炎的病例。
结果
两例均发生在紫杉醇（180mg/m²）和阿霉素（75mg/m²）联合治疗的第一个周期，二者同时进行72小时持续静脉输注。
结论
两例盲肠炎发生于紫杉醇和阿霉素联合治疗后，而单独使用其中任何一种药物治疗后均未发现有盲肠炎的报道。
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