正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）受体显像：聚焦于阿片受体。

Receptor imaging by PET and SPECT: focus on the opiate receptor.

作者信息

Frost J J

机构信息

Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.

出版信息

J Recept Res. 1993;13(1-4):39-53. doi: 10.3109/10799899309073644.

DOI:10.3109/10799899309073644

PMID:8095556

Abstract

Receptor imaging by PET and SPECT offers distinctive advantages over the more established flow/metabolism imaging methods, including improved chemical specificity and improved sensitivity in detecting changes in disease. Radioligands are available for PET and SPECT imaging of many neuroreceptors including the opiate receptor, the dopamine receptor and the muscarinic cholinergic receptor. A new focus of interest is the imaging and quantification of presynaptic neurotransmitter reuptake sites. Clinical applications of mu opiate receptor imaging are discussed for epilepsy, Alzheimer's disease and dementia.

摘要

与更成熟的血流/代谢成像方法相比，正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）受体成像具有独特优势，包括提高化学特异性以及在检测疾病变化方面提高灵敏度。有多种放射性配体可用于PET和SPECT对许多神经受体进行成像，包括阿片受体、多巴胺受体和毒蕈碱型胆碱能受体。一个新的关注焦点是突触前神经递质再摄取位点的成像和定量分析。本文讨论了μ阿片受体成像在癫痫、阿尔茨海默病和痴呆症方面的临床应用。