Wu J K, Folkerth R D, Ye Z, Darras B T
Department of Neurosurgery, New England Medical Center, Boston, Massachusetts.
J Neurooncol. 1993 Jan;15(1):29-35. doi: 10.1007/BF01050260.
Oligodendrogliomas are indolent brain tumors with mean postoperative survival of about 5 years. However, the range of postoperative survivals is wide, suggesting that these tumors are heterogeneous in their biologic behavior. Using restriction fragment length polymorphism (RFLP) analysis, we studied a case of an oligodendroglioma with loss of chromosome 10 sequences, a finding that has only been reported in glioblastoma multiforme and anaplastic astrocytomas. Four and a half months after the initial surgery the patient returned with a recurrent tumor having classic radiologic and pathologic features of glioblastoma multiforme. Loss of chromosome 10 alleles in oligodendroglioma may be predictive of aggressive biologic behavior, even in the absence of recognized histopathologic characteristics of anaplasia, and may enable us to select more appropriate treatments for this group of patients.
少突胶质细胞瘤是一种生长缓慢的脑肿瘤，术后平均生存期约为5年。然而，术后生存期范围很广，这表明这些肿瘤的生物学行为存在异质性。我们利用限制性片段长度多态性（RFLP）分析研究了1例10号染色体序列缺失的少突胶质细胞瘤病例，该发现仅在多形性胶质母细胞瘤和间变性星形细胞瘤中报道过。初次手术后4个半月，患者因复发性肿瘤再次就诊，该肿瘤具有多形性胶质母细胞瘤典型的影像学和病理学特征。少突胶质细胞瘤中10号染色体等位基因的缺失可能预示着侵袭性生物学行为，即使在没有公认的间变组织病理学特征的情况下也是如此，这可能使我们能够为这组患者选择更合适的治疗方法。
