Ludwig C L, Smith M T, Godfrey A D, Armbrustmacher V W
Ann Neurol. 1986 Jan;19(1):15-21. doi: 10.1002/ana.410190104.
All patients with oligodendrogliomas (554) from the repository of the Armed Forces Institute of Pathology were retrospectively analyzed. The pathological diagnosis was confirmed in 323 patients and each case was graded according to a previously established grading system. The clinical features of these 323 verified cases of oligodendroglioma are presented, analyzed, and compared with findings in previous studies. There is a significant age skew according to tumor grade, with 68% of patients with grade A tumors under 40 years and 83% of patients with grade D tumors over 40 years of age. Headache was the most common symptom, followed by seizure, visual loss, papilledema, paralysis, and dementia. No symptoms showed a statistically significant correlation with tumor grade. However, tumor grading allowed significant prognostic statements to be made. Attention is drawn to several often neglected symptoms of oligodendrogliomas: ataxia, hemorrhage, stroke, and cerebrospinal fluid spread. This is, to our knowledge, the largest clinicopathological study of oligodendrogliomas to date.
对来自武装部队病理研究所数据库的所有少突胶质细胞瘤患者（554例）进行了回顾性分析。323例患者的病理诊断得到证实，每例病例均根据先前建立的分级系统进行分级。呈现并分析了这323例经证实的少突胶质细胞瘤病例的临床特征，并与先前研究结果进行了比较。根据肿瘤分级存在明显的年龄偏差，A级肿瘤患者中68%年龄在40岁以下，D级肿瘤患者中83%年龄在40岁以上。头痛是最常见的症状，其次是癫痫发作、视力丧失、视乳头水肿、瘫痪和痴呆。没有症状与肿瘤分级存在统计学上的显著相关性。然而，肿瘤分级有助于做出重要的预后判断。需要注意少突胶质细胞瘤的几种常被忽视的症状：共济失调、出血、中风和脑脊液播散。据我们所知，这是迄今为止关于少突胶质细胞瘤最大规模的临床病理研究。
