免疫佐剂的作用方式。I. 一种评估以分枝杆菌佐剂为代表的物质的佐剂效应的新方法。
The mode of action of immunological adjuvants. I. A new method to assess the adjuvant effect of substances as represented by mycobacterial adjuvants.
作者信息
Tanaka A, Ishibashi T, Koashi O, Koga T, Sugiyama K
出版信息
Jpn J Exp Med. 1975 Jun;45(3):139-46.
PMID:809606
Abstract
When mice were sensitized with sheep red blood cells (SRBC), the addition of adjuvant-active substances to the sensitizing antigen resulted in a highly significant increase in the mean diameter of plaques developed by spleen cells as measured by Jerne's plaque technique. The increase in plaque diameter was found to be a good measure for the adjuvant effect of such substances as mycobacterial adjuvants, because the phenomenon is specific, reproducible, sensitive and can be tested using a few number of mice.
摘要
当用绵羊红细胞（SRBC）使小鼠致敏时，在致敏抗原中添加佐剂活性物质会导致通过耶尔恩氏空斑技术测量的脾细胞形成的空斑平均直径显著增加。发现空斑直径的增加是衡量诸如分枝杆菌佐剂等物质佐剂效应的良好指标，因为该现象具有特异性、可重复性、敏感性，并且可以使用少量小鼠进行测试。
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