Benzodiazepines and addiction.

Benzodiazepines are medications that are addicting--both in combination with other drugs and alone. The scope of the problem is thought to be wide, but it has not been well documented for unclear reasons. Pharmacologic dependence has been documented in virtually all long-term users. Adverse effects occur secondary to their use and these effects are often subtle, but significant. Various benzodiazepines present differences in reinforcement, withdrawal, and adverse effects. Diagnostic issues, withdrawal, and treatment issues are discussed.