Lindblad U, Råstam L, Ranstam J
Department of Community Health Sciences, University of Lund, Malmö, Sweden.
J Intern Med. 1993 Feb;233(2):155-63. doi: 10.1111/j.1365-2796.1993.tb00668.x.
Stroke incidence was analysed in a Swedish cohort of male (n = 1428) and female (n = 1812) hypertensive patients in comparison with age- and sex-matched population controls (1:1) and with normotensive untreated subjects (1249 men and 1247 women). Mean follow-up was 8.3 years. Patients were aged 40-69 at the start of follow-up in 1977-1981. Relative risks (95% confidence interval [CI]) for stroke morbidity were 1.63 (1.16, 2.29) for men and 1.40 (0.94, 2.09) for women compared to population controls. Corresponding figures for stroke mortality were 1.96 (1.01-3.82) and 1.48 (0.71-3.06). Compared to the normotensive sample with adjustment for smoking and body mass index relative risks for stroke morbidity were 3.07 (1.96-4.80) for men and 2.56 (1.46-4.51) for women. The prognosis of treated hypertension with respect to stroke is better than anticipated from previous studies, a fact that should be considered when treatment guidelines are developed.
对瑞典一组男性（n = 1428）和女性（n = 1812）高血压患者的中风发病率进行了分析，并与年龄和性别匹配的人群对照（1:1）以及未接受治疗的血压正常受试者（1249名男性和1247名女性）进行比较。平均随访时间为8.3年。患者在1977 - 1981年随访开始时年龄为40 - 69岁。与人群对照相比，男性中风发病率的相对风险（95%置信区间[CI]）为1.63（1.16，2.29），女性为1.40（0.94，2.09）。中风死亡率的相应数字分别为1.96（1.01 - 3.82）和1.48（0.71 - 3.06）。与经吸烟和体重指数调整的血压正常样本相比，男性中风发病率的相对风险为3.07（1.96 - 4.80），女性为2.56（1.46 - 4.51）。高血压治疗对中风的预后比先前研究预期的要好，在制定治疗指南时应考虑这一事实。
