Schechter M D, Meehan S M
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
Eur J Pharmacol. 1993 Feb 23;232(1):135-8. doi: 10.1016/0014-2999(93)90739-5.
Previous work has indicated that the psychostimulant cathinone produces a location preference in the conditioned place preference task. The present study expanded upon this earlier work by examining the dose-response nature of cathinone-induced conditioned place preference, as well as testing its effect upon spontaneous locomotor activity. At doses ranging from 0.2 to 1.6 mg/kg, cathinone produced a conditioned place preference at all but the lowest dose, and the highest dose but not the lowest dose increased locomotor activity. Results are discussed in terms of dopaminergic mediation of conditioned place preference and the relationship between conditioned place preference and locomotion being subserved by the same neuronal system.
先前的研究表明，精神刺激剂卡西酮在条件性位置偏爱任务中会产生位置偏爱。本研究在早期工作的基础上进行了扩展，研究了卡西酮诱导的条件性位置偏爱的剂量反应特性，并测试了其对自发运动活性的影响。在0.2至1.6毫克/千克的剂量范围内，除最低剂量外，卡西酮在所有剂量下均产生了条件性位置偏爱，且最高剂量而非最低剂量增加了运动活性。从多巴胺能介导条件性位置偏爱以及条件性位置偏爱与运动之间的关系由同一神经元系统维持的角度对结果进行了讨论。
