静脉注射同种异体细胞可使T淋巴细胞具备细胞毒性活性。
Intravenous injection of allogeneic cells can prime T-lymphocytes with cytotoxic activity.
作者信息
Kronin V V, Anosova N G, Popov I A, Polesskaya A N, Brondz B D, Krivoshein Y S
机构信息
Institute of Carcinogenesis, Cancer Research Center, Moscow, Russia.
出版信息
Immunol Lett. 1993 Jan;35(1):13-8. doi: 10.1016/0165-2478(93)90141-n.
The possibility of specific cytotoxic T-lymphocyte (CTL)2 induction was shown upon intravenous (i.v.) immunization of mice with 9 x 10(7) irradiated (2000 rad) allogeneic splenocytes. The induced CTL express the cell surface markers Thy1.2+, L3T4- and Lyt2+. No correlation between the level of cytotoxic activity and the ability to inhibit proliferation was shown in populations of lymphocytes, primed both by i.v. immunization and in mixed lymphocyte culture (MLC). The possible role of cytotoxic activity in down-regulation of the immune response is discussed.
在用9×10⁷经照射（2000拉德）的同种异体脾细胞对小鼠进行静脉内免疫后，显示出诱导特异性细胞毒性T淋巴细胞（CTL）2的可能性。诱导的CTL表达细胞表面标志物Thy1.2⁺、L3T4⁻和Lyt2⁺。在通过静脉内免疫和混合淋巴细胞培养（MLC）引发的淋巴细胞群体中，未显示出细胞毒性活性水平与抑制增殖能力之间的相关性。讨论了细胞毒性活性在免疫反应下调中的可能作用。
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