[通过小鼠静脉免疫诱导同种异体抗原特异性细胞毒性T淋巴细胞]
[The induction of alloantigen-specific cytotoxic T-lymphocytes by the intravenous immunization of mice].
作者信息
Krivoshein Iu S, Anosova N G, Brondz B D, Kronin V V, Popov I A
出版信息
Mikrobiol Z. 1994 May-Jun;56(3):31-5.
PMID:7524958
Abstract
It is shown possible to induce specific cytotoxic T-lymphocytes (CTL) in the course of intravenous (i.v.) immunization of Balb/c mice by 2000-rad-irradiated allogeneic C57Bl/6 splenocytes in a dose of 9 x 10(7). The induced CTL express Thy1.2+L3T4-Ly2+ cell surface markers. No correlation was observed between the level of cytotoxic activity and the ability to inhibit proliferation in the population of lymphocytes primed by i.v. immunization.
摘要
结果表明，在给Balb/c小鼠静脉内（i.v.）免疫过程中，用剂量为9×10⁷的经2000拉德照射的同种异体C57Bl/6脾细胞有可能诱导出特异性细胞毒性T淋巴细胞（CTL）。诱导出的CTL表达Thy1.2⁺L3T4⁻Ly2⁺细胞表面标志物。在静脉内免疫引发的淋巴细胞群体中，细胞毒性活性水平与抑制增殖能力之间未观察到相关性。
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