Marino A, Costa R
Istituto di Farmacologia Sperimentale e Clinica, Università Federico II, Napoli.
Recenti Prog Med. 1993 Feb;84(2):129-41.
Anxiety disorders are widely present in general population. Epidemiology studies evaluated a 5-10% prevalence of these disorders, whose social impact needs an early diagnosis and an adequate treatment. In recent years, behavioural, neurochemical and pharmacological researches allowed the characterization of several types of pathological anxiety and a new consideration of nosography in order to establish a correct treatment. In particular, a remarkable progress of the knowledge of biological bases of anxiety resulted from study of anxiety animal models and of mechanisms of action of anxiolytic drugs. On this regard mechanism involving GABAergic, serotoninergic and cholecystokininergic were suggestive.
焦虑症在普通人群中广泛存在。流行病学研究评估了这些疾病5%-10%的患病率，其社会影响需要早期诊断和适当治疗。近年来，行为学、神经化学和药理学研究使得几种病理性焦虑得以特征化，并对疾病分类学有了新的认识，以便确立正确的治疗方法。特别是，对焦虑动物模型和抗焦虑药物作用机制的研究使焦虑生物学基础的知识取得了显著进展。在这方面，涉及γ-氨基丁酸能、5-羟色胺能和胆囊收缩素能的机制具有启发性。
