Talalaenko A N
Zh Vyssh Nerv Deiat Im I P Pavlova. 1993 May-Jun;43(3):621-6.
Chemical stimulation of the dorsal hippocampus by serotonin and GABA decreases anxiety in a test of avoidance of precarious situation but not of illuminated platform. Intrahippocampal injection of chlordiazepoxide induced similar effect. Microinjection of glutamic acid into the hippocampus increases and that of dopamine decreases anxiety in the test of avoidance of illuminated platform but not of precarious situation. Ipsapiron locally injected unto the dorsal hippocampus induces antiaversive effect counteracting anxiety states in both behavioural models. A conclusion is drown that hippocampal monoanin- and acidergic mechanisms are functionally different in anxiety of different modes of aversive origin. Differences in spectra of anxiolytic action of chlordiazepoxide and ipsapiron may be underlied by nonsimilar degree of involvement of these transmitter mechanisms in anxiety states being formed by aversive influences of different biological significance.
血清素和γ-氨基丁酸对背侧海马体的化学刺激在避免不稳定情境而非有光照平台的测试中可减轻焦虑。海马体内注射氯氮卓可产生类似效果。在避免有光照平台而非不稳定情境的测试中，向海马体微量注射谷氨酸会增加焦虑，而注射多巴胺则会减轻焦虑。局部注射伊沙匹隆到背侧海马体在两种行为模型中均诱导产生抵消焦虑状态的抗厌恶作用。得出的结论是，海马体单胺能和酸性机制在不同厌恶源模式的焦虑中功能不同。氯氮卓和伊沙匹隆抗焦虑作用谱的差异可能是由于这些递质机制在由具有不同生物学意义的厌恶影响所形成的焦虑状态中的参与程度不同所致。
