Jeevaratnam K, Sugendran K, Vaidyanathan C S
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India.
Hum Exp Toxicol. 1993 Mar;12(2):135-9. doi: 10.1177/096032719301200207.
The subcutaneous administration of methyl isocyanate (MIC) to female rabbits, resulted in significant increases in haemoglobin concentration, erythrocyte volume fraction and leucocyte number in blood, as well as plasma total proteins, and urea. The present study was designed to investigate whether the hydrolytic products of MIC, methylamine (MA) and N,N'-dimethylurea (DMU) play any role in eliciting these changes. Both MA and DMU administered subcutaneously in an equimolar dose to that of 1.0 LD50 MIC, 2.2 mmol kg-1, had no influence on these parameters, although there was a marginal increase in the plasma urea level shortly after the administration of DMU. This study establishes that the observed haematological and biochemical changes induced by MIC intoxication in rabbits are mostly due to MIC.
对雌性兔子皮下注射甲基异氰酸酯（MIC）后，血液中的血红蛋白浓度、红细胞体积分数和白细胞数量以及血浆总蛋白和尿素均显著增加。本研究旨在调查MIC的水解产物甲胺（MA）和N，N'-二甲基脲（DMU）在引发这些变化中是否起任何作用。以与1.0 LD50 MIC（2.2 mmol kg-1）等摩尔剂量皮下注射MA和DMU，对这些参数均无影响，尽管在注射DMU后不久血浆尿素水平略有升高。本研究证实，兔子因MIC中毒而观察到的血液学和生化变化主要是由MIC引起的。
