抗淋巴细胞球蛋白（ALG）的临床应用（作者译）
[The clinical use of antilymphocyte globulin (ALG) (author's transl)].
作者信息
Brendel W, Seifert J, Ring J
出版信息
MMW Munch Med Wochenschr. 1975 Aug 29;117(35):1361-8.
ALG is mainly used for immunosuppressive treatment following organ transplants. Controlled clinical trials demonstrated the efficacy of ALG in kidney, bone marrow and skin transplantation. Pilot studies describe a therapeutic effect in human autoaggression. A possible therapeutic effect, however, depends upon the strict observation of the following criteria: 1. Adequate dosage (20 mg/kg and more). 2. Intravenous application. 3. Suppression of sensitization against xenogeneic globulin by induction of immunological unresponsiveness before ALG-treatment (prevention of allergic complications and increase of ALG efficacy). Previously published negative results with ALG can be explained by failure to comply with the above criteria.
抗淋巴细胞球蛋白主要用于器官移植后的免疫抑制治疗。对照临床试验证明了抗淋巴细胞球蛋白在肾脏、骨髓和皮肤移植中的疗效。初步研究描述了其在人类自身免疫性疾病中的治疗作用。然而，可能的治疗效果取决于严格遵守以下标准：1. 足够的剂量（20毫克/千克及以上）。2. 静脉给药。3. 在抗淋巴细胞球蛋白治疗前通过诱导免疫无反应性来抑制对异种球蛋白的致敏（预防过敏并发症并提高抗淋巴细胞球蛋白疗效）。先前发表的关于抗淋巴细胞球蛋白的阴性结果可以通过未遵守上述标准来解释。
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