Hirschberger J, Goldberg M, Sauer U G
I. Medizinische Tierklinik, University of Munich, Federal Republic of Germany.
Eur J Clin Chem Clin Biochem. 1993 Feb;31(2):103-6. doi: 10.1515/cclm.1993.31.2.103.
The amino acid pattern in the ascites of 79 dogs was examined. The concentration of glutamine in neoplastic ascites is significantly lower than in cardial effusions. In contrast, glutamate is significantly higher in neoplastic ascites than in cardial ascites. Using an arbitrary discrimination value of 0.28 for the glutamate/glutamine ratio, purulent or cardial ascites are easily differentiated, with a sensitivity of 100% and a specificity of 94%. The differentiation is very distinct, with no overlap between the group of patients with liver cirrhosis on the one hand and the groups of patients with purulent peritonitis, heart failure, or malignant ascites on the other hand. There was no diagnostically unsable correlation between the concentrations of the other 20 amino acids and the underlying causes of ascites formation.
对79只犬的腹水氨基酸模式进行了检测。肿瘤性腹水中谷氨酰胺的浓度显著低于心性积液中的浓度。相反，肿瘤性腹水中谷氨酸盐的含量显著高于心性腹水中的含量。以谷氨酸盐/谷氨酰胺比值0.28作为任意判别值，可轻松区分脓性或心性腹水，敏感性为100%，特异性为94%。这种区分非常明显，一方面肝硬化患者组与另一方面脓性腹膜炎、心力衰竭或恶性腹水患者组之间没有重叠。其他20种氨基酸的浓度与腹水形成的潜在原因之间不存在诊断上无用的相关性。
