Bidzseranova A, Varga J, Telegdy G
Institute of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Eur J Pharmacol. 1993 Mar 2;232(2-3):305-8. doi: 10.1016/0014-2999(93)90790-o.
Partial amnesia was induced in rats by electroconvulsive shock (ECS) immediately after passive avoidance learning. This partial amnesia could be prevented by administering porcine brain natriuretic peptide-32 (pBNP-32) into the lateral brain ventricle. The effects of pretreatment with different receptor blockers (haloperidol, atropine, phenoxybenzamine, propranolol, naloxone, bicuculline and methysergide) on the pBNP-32-induced antiamnesia were investigated. In the doses selected, the blockers had no influence on the ECS-induced amnesia. Haloperidol, atropine, phenoxybenzamine and propranolol blocked the antiamnesic action of the peptide, while naloxone, bicuculline and methysergide were ineffective. These results suggest that pBNP-32 may influence learning processes and that the antiamnesic action of this peptide is mediated by dopaminergic, cholinergic alpha- and beta-adrenergic mediator systems.
在被动回避学习后立即通过电惊厥休克（ECS）诱导大鼠出现部分失忆。通过向侧脑室注射猪脑利钠肽-32（pBNP-32）可预防这种部分失忆。研究了用不同受体阻滞剂（氟哌啶醇、阿托品、酚苄明、普萘洛尔、纳洛酮、荷包牡丹碱和麦角新碱）预处理对pBNP-32诱导的抗失忆作用的影响。在所选用的剂量下，这些阻滞剂对ECS诱导的失忆没有影响。氟哌啶醇、阿托品、酚苄明和普萘洛尔可阻断该肽的抗失忆作用，而纳洛酮、荷包牡丹碱和麦角新碱则无效。这些结果表明，pBNP-32可能影响学习过程，并且该肽的抗失忆作用是由多巴胺能、胆碱能α和β肾上腺素能介质系统介导的。
