Kovács A, Telegdy G
Department of Pathophysiology, A. Szent-Györgyi Medical University, Szeged, Hungary.
Pharmacol Biochem Behav. 1994 Jan;47(1):121-5. doi: 10.1016/0091-3057(94)90120-1.
The effects of calcitonin gene-related peptide (CGRP) on electroconvulsive shock (ECS)-induced amnesia and the possible involvement of neurotransmitters in this action were studied in rats. ECS-induced amnesia was elicited in a passive avoidance paradigm. The possible roles of different transmitters involved in mediating CGRP action were followed by pretreating the animals with different receptor blockers in doses which themselves could not influence the paradigm. CGRP facilitated learning in the passive avoidance paradigm and prevented ECS-induced amnesia in a dose-dependent manner. Pretreatment with atropine, naloxone, phenoxybenzamine, or propranolol blocked the antiamnesic action of CGRP. Other receptor blockers, such as bicuculline, methysergide, and haloperidol, were ineffective. The results support our previous findings that CGRP facilitates passive avoidance learning and prevents ECS-induced amnesia. In the antiamnesic action of CGRP, cholinergic, opiate, and alpha- and beta-adrenergic mediators are involved.
在大鼠中研究了降钙素基因相关肽（CGRP）对电惊厥休克（ECS）诱导的失忆的影响以及神经递质在该作用中可能的参与情况。在被动回避范式中诱发ECS诱导的失忆。通过用本身不会影响该范式的剂量的不同受体阻滞剂预处理动物，来研究参与介导CGRP作用的不同递质的可能作用。CGRP以剂量依赖性方式促进被动回避范式中的学习并预防ECS诱导的失忆。用阿托品、纳洛酮、酚苄明或普萘洛尔预处理可阻断CGRP的抗失忆作用。其他受体阻滞剂，如荷包牡丹碱、甲基麦角新碱和氟哌啶醇，则无效。这些结果支持我们之前的发现，即CGRP促进被动回避学习并预防ECS诱导的失忆。在CGRP的抗失忆作用中，涉及胆碱能、阿片类以及α和β肾上腺素能介质。
