血管紧张素转换酶基因缺失多态性与心肌梗死家族史相关。
Deletion polymorphism in angiotensin-converting enzyme gene associated with parental history of myocardial infarction.
作者信息
Tiret L, Kee F, Poirier O, Nicaud V, Lecerf L, Evans A, Cambou J P, Arveiler D, Luc G, Amouyel P
机构信息
INSERM U258, Paris, France.
出版信息
Lancet. 1993 Apr 17;341(8851):991-2. doi: 10.1016/0140-6736(93)91075-w.
In a European study an insertion (I)/deletion (D) polymorphism in the angiotensin converting enzyme (ACE) gene has been shown to be associated with the risk of myocardial infarction (MI). In the same study, we investigated the association of the polymorphism with a parental history of fatal MI. There was an excess of both DD (odds ratio 2.6, p = 0.02) and ID (odds ratio = 1.9, p = 0.08) genotypes among those having a parental history of MI, confirming that genetic variation in the ACE locus could be involved in the risk of MI.
在一项欧洲研究中，血管紧张素转换酶（ACE）基因中的插入（I）/缺失（D）多态性已被证明与心肌梗死（MI）风险相关。在同一研究中，我们调查了该多态性与致命性心肌梗死家族史之间的关联。在有心肌梗死家族史的人群中，DD基因型（优势比2.6，p = 0.02）和ID基因型（优势比 = 1.9，p = 0.08）均过量，证实ACE基因座的遗传变异可能与心肌梗死风险有关。
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