Fage D, Carboni S, Voltz C, Scatton B, Carter C
Synthelabo Recherche (LERS), Biology Department, Bagneux, France.
Neurosci Lett. 1993 Jan 12;149(2):173-6. doi: 10.1016/0304-3940(93)90764-c.
Dialysis probe implantation in the rat parietal cortex results in delayed, prolonged and biphasic increases in the efflux of putrescine and spermidine with primary and secondary efflux peaks 6-8 h and 20-24 h after implantation. Putrescine and spermidine efflux remain elevated for at least 30 h after implantation. The primary efflux peak is attenuated by the continual infusion via the dialysis probe of either the ornithine decarboxylase inhibitor difluoromethylornithine or by the NMDA antagonist 2-APV. The secondary peak is resistant to either of these treatments. These changes in polyamine outflow are likely related to the traumatic brain damage associated with dialysis probe implantation which may be a useful model to study the effects of local brain trauma.
将透析探针植入大鼠顶叶皮层会导致腐胺和亚精胺外流出现延迟、延长且双相的增加，植入后6 - 8小时和20 - 24小时分别出现原发性和继发性外流峰值。植入后腐胺和亚精胺外流至少持续升高30小时。通过透析探针持续输注鸟氨酸脱羧酶抑制剂二氟甲基鸟氨酸或NMDA拮抗剂2 - APV可减弱原发性外流峰值。继发性峰值对这两种处理均有抗性。多胺流出的这些变化可能与透析探针植入相关的创伤性脑损伤有关，这可能是研究局部脑损伤影响的有用模型。
