Badolo L, Dubois J, Helson-Cambier M, Hanocq M
Laboratory of Bioanalytical Chemistry, Toxicology and Applied Physical Chemistry, Institute de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium.
Eur J Pharmacol. 1998 Jan 26;342(2-3):R1-R2. doi: 10.1016/s0014-2999(97)01601-4.
Ifenprodil (NMDA receptor antagonist) was tested as an inhibitor of ornithine decarboxylase. It was found that ifenprodil inhibited ornithine decarboxylase activity with the same potency as alpha-difluoromethylornithine, a major inhibitor of ornithine decarboxylase. This result suggests that ifenprodil could target either the polyamine site on the NMDA receptor complex or/and polyamine biosynthesis.
艾芬地尔（NMDA受体拮抗剂）作为鸟氨酸脱羧酶抑制剂进行了测试。结果发现，艾芬地尔抑制鸟氨酸脱羧酶活性的效力与α-二氟甲基鸟氨酸相同，α-二氟甲基鸟氨酸是鸟氨酸脱羧酶的主要抑制剂。这一结果表明，艾芬地尔可能作用于NMDA受体复合物上的多胺位点或/和多胺生物合成过程。
