Balldin J, Berggren U, Eriksson E, Lindstedt G, Sundkler A
Department of Psychiatry and Neurochemistry, Mölndal Hospital, University of Göteborg, Sweden.
Psychoneuroendocrinology. 1993;18(1):45-55. doi: 10.1016/0306-4530(93)90054-o.
Doses of 0.5 mg and 1.0 mg of the alpha-2-adrenoceptor agonist guanfacine (GUA) and NaCl were administered intravenously (IV) in a randomized order to 18 healthy male subjects. GUA induced growth hormone (GH) secretion in a dose-dependent manner without affecting blood pressure or heart rate or inducing sedation. The effects of GUA 1.5 mg i.v. was compared with those of another alpha-2-adrenoceptor agonist, clonidine (CLON) 150 micrograms i.v. in six other male volunteers. Both alpha-2-agonists increased GH to similar levels. CLON reduced both systolic and diastolic blood pressure levels, whereas GUA reduced only systolic levels. Sedation was significantly more pronounced after CLON. The results suggest that the GUA/GH-test (1.5 mg GUA i.v.) may be an alternative to the CLON/GH-test in neuroendocrine assessment of alpha-2-adrenoceptor sensitivity.
将0.5毫克和1.0毫克的α-2肾上腺素能受体激动剂胍法辛（GUA）以及氯化钠以随机顺序静脉注射给18名健康男性受试者。胍法辛以剂量依赖性方式诱导生长激素（GH）分泌，而不影响血压或心率，也不引起镇静作用。将静脉注射1.5毫克胍法辛的效果与静脉注射150微克另一种α-2肾上腺素能受体激动剂可乐定（CLON）在另外6名男性志愿者中的效果进行了比较。两种α-2激动剂均将生长激素升高至相似水平。可乐定降低了收缩压和舒张压水平，而胍法辛仅降低了收缩压水平。可乐定后的镇静作用明显更显著。结果表明，在α-2肾上腺素能受体敏感性的神经内分泌评估中，胍法辛/生长激素试验（静脉注射1.5毫克胍法辛）可能是可乐定/生长激素试验的替代方法。
