Hoehe M, Valido G, Matussek N
Psychiatric Hospital, University of Munich, F.R.G.
Psychoneuroendocrinology. 1988;13(5):409-18. doi: 10.1016/0306-4530(88)90047-9.
The growth hormone (GH) response to clonidine (CLON) has been investigated to date mostly with CLON doses of 2.0 micrograms/kg or 150 micrograms intravenously (IV). The present study investigated GH and blood pressure (BP) responses to CLON (2.0 and 1.5 micrograms/kg IV) (Study I). Twelve healthy male volunteers were tested with the two CLON doses and saline in a cross-randomized design. Plasma GH, noradrenaline (NA) and cortisol concentrations, BP and sedation were determined. CLON (1.5 and 2.0 micrograms/kg) induced a significant dose-dependent GH increase, but only the 2.0 micrograms/kg dose differentiated GH responders from nonresponders. In contrast to GH, NA, cortisol, and BP did not differ significantly after either CLON dose. We also studied GH responses to repeated CLON stimulation (Study II). Ten healthy male volunteers were given four CLON tests (2.0 micrograms/kg) at three-week intervals. The nine volunteers who participated in both studies were investigated over a time course up to 21 months. The subjects could be classified into those who showed consistent GH responses greater than 5 ng/ml, those who showed consistent GH responses less than 5 ng/ml, and those who showed both degrees of responses.
迄今为止，大多采用2.0微克/千克的可乐定（CLON）剂量或150微克静脉注射（IV）来研究生长激素（GH）对可乐定的反应。本研究调查了GH和血压（BP）对可乐定（2.0和1.5微克/千克IV）的反应（研究I）。12名健康男性志愿者采用交叉随机设计，接受了两种可乐定剂量和生理盐水的测试。测定了血浆GH、去甲肾上腺素（NA）和皮质醇浓度、血压和镇静程度。可乐定（1.5和2.0微克/千克）引起了显著的剂量依赖性GH升高，但只有2.0微克/千克剂量能区分GH反应者和无反应者。与GH不同，两种可乐定剂量后NA、皮质醇和血压均无显著差异。我们还研究了GH对重复可乐定刺激的反应（研究II）。10名健康男性志愿者每隔三周接受4次可乐定测试（2.0微克/千克）。参与两项研究的9名志愿者在长达21个月的时间内接受了调查。受试者可分为GH反应持续大于5纳克/毫升的、GH反应持续小于5纳克/毫升的以及两种反应程度都有的。
