Carvey P M, Ptak L R, Nath S T, Sierens D K, Mufson E J, Goetz C G, Klawans H L
Department of Neurological Sciences, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612.
Exp Neurol. 1993 Mar;120(1):149-52. doi: 10.1006/exnr.1993.1049.
The caudate, putamen, and cerebellum from five patients with Parkinson's disease (PD) and five normal, aged controls were studied to determine if cell-free extracts from these tissues influenced dopamine neuron growth in culture. Cultures incubated with extracts of the caudate and putamen, but not the cerebellum, from PD patients contained more tyrosine hydroxylase immunoreactive neurons than aged controls. These data suggest that the parkinsonian striatum compensates for dopamine loss by increasing neurotrophic factor production.
对五名帕金森病（PD）患者和五名正常老年对照者的尾状核、壳核及小脑进行研究，以确定这些组织的无细胞提取物是否会影响培养中的多巴胺能神经元生长。与帕金森病患者的尾状核和壳核提取物（而非小脑提取物）一起孵育的培养物中，酪氨酸羟化酶免疫反应性神经元比老年对照者更多。这些数据表明，帕金森病纹状体通过增加神经营养因子的产生来补偿多巴胺的损失。
