可溶性鸟苷酸环化酶α3和β3亚基编码基因定位于人染色体4的q31.3 - q33处。

Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.

作者信息

Giuili G, Roechel N, Scholl U, Mattei M G, Guellaen G

机构信息

Institut National de la Santé et de la Recherche Médicale (INSERM), U-99, Hôpital Henri Mondor, Créteil, France.

出版信息

Hum Genet. 1993 Apr;91(3):257-60. doi: 10.1007/BF00218267.

DOI:10.1007/BF00218267

PMID:8097486

Abstract

We have determined the chromosomal location of the human genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase (GC-S). The study was performed by in situ hybridization of human metaphase spreads with two human cDNA probes, containing the coding sequences of the GC-S alpha 3 and beta 3 subunits, respectively. Each probe gave a strong specific signal on chromosome 4 at the 4q31.3-4q33 region, with the maximal signal in the 4q32 band. The colocalization of both genes in 4q32 represents an interesting feature for the coordinated regulation of expression of both GC-S subunits.

摘要

我们已经确定了编码可溶性鸟苷酸环化酶（GC-S）α3和β3亚基的人类基因的染色体定位。该研究通过用人中期染色体铺片与两个人类cDNA探针进行原位杂交来进行，这两个探针分别包含GC-Sα3和β3亚基的编码序列。每个探针在4号染色体的4q31.3-4q33区域都给出了强烈的特异性信号，在4q32带信号最强。这两个基因在4q32区域的共定位对于GC-S两个亚基表达的协调调控而言是一个有趣的特征。