通过原位杂交将DNA探针定位在18p11.3带，并鉴定出一条小的额外染色体。
DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome.
作者信息
Mattei M G, Philip N, Passage E, Moisan J P, Mandel J L, Mattei J F
出版信息
Hum Genet. 1985;69(3):268-71. doi: 10.1007/BF00293038.
PMID:3980018
Abstract
Recombinant plasmid clone B74 (also named D18 S3) containing a human single-copy DNA segment of 6 kilobases (kb) was localized by in situ hybridization on band p113 of chromosome 18. This probe was then used in cytogenetic diagnosis to identify precisely a small supernumerary chromosome as an isochromosome i(18p).
摘要
包含一段6千碱基（kb）人类单拷贝DNA片段的重组质粒克隆B74（也称为D18 S3）通过原位杂交定位在18号染色体的p113带上。然后该探针被用于细胞遗传学诊断，以准确鉴定一条小的额外染色体为等臂染色体i(18p)。
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