Perlemuter L, Hazard J, Kazatchkine M, Guilhaume B, Bernheim R
Nouv Presse Med. 1975 Oct 4;4(32):2307-10.
A study was performed on the effects of carbamazepine and of clofibrate in 7 cases of diabetes insipidus of high origin. In 4 cases the action of the two substances used in association was studied. Carbamazepine, in a dose of 0.60 g/day was effective in all cases with negativisation of free water clearance in 5 out of 7. Clofibrate, in a dose of 1.50 g/day was effective in 4 cases out of 7 with negativation of free water clearance in 2. Both medications act by provoking the secretion of anti-diuretic hormone by the hypothalamic/posterior pituitary centres and are thus only active if a minimal secretion of ADH is still possible. There is no apparent potentialisation of the two substances, which both require a minimal possibility of ADH secretion to be active. There is no diminution in the ADH secretor effect, since both products remain active for as long as they are given, making it possible to observe in 3 out of 7 cases spontaneous cure of the diabetes insipidus, allowing suppression of the treatment.
对7例高位性尿崩症患者进行了卡马西平和氯贝丁酯疗效的研究。对其中4例患者研究了联合使用这两种药物的作用。卡马西平剂量为0.60g/天，对所有病例均有效，7例中有5例自由水清除率转为阴性。氯贝丁酯剂量为1.50g/天，7例中有4例有效，2例自由水清除率转为阴性。两种药物均通过刺激下丘脑/垂体后叶中心分泌抗利尿激素起作用，因此只有在抗利尿激素仍有最低限度分泌的情况下才有效。两种药物没有明显的增效作用，二者发挥作用均需要抗利尿激素有最低限度的分泌可能性。抗利尿激素分泌效应没有减弱，因为两种药物只要持续给药就保持活性，7例中有3例尿崩症出现自发缓解，从而可以停止治疗。
